The Los Angeles Times published its NFL Week 4 predictions on September 25, 2025, with analysis from staff writer Sam Farmer. The article detailed Farmer's picks for the weekend's slate of games, noting his season record of 32-16 through the first three weeks.
- Farmer predicted the Baltimore Ravens would defeat the Kansas City Chiefs.
- The Los Angeles Rams are expected to beat the Indianapolis Colts in what is anticipated to be one of the weekend's best games.
- The forecast also projected the Philadelphia Eagles would defeat the Tampa Bay Buccaneers.
- A victory for the Eagles would advance their season record to 4-0.
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